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Peer review Peer review information Nature Communications thanks the anonymous reviewers for their contribution to the peer review of this work

Spitz FR, Kataoka M, Sarkiss M, Meyn R, McDonnell TJ, Swisher S , Cristiano RJ, Roth JA

18.2.1 Grupo educativo y colectivos destinatarios establecidos por los signatarios

Under the therapeutic concentrations, approximately 60%90% of APAP is metabolized in the liver by glucuronidation and sulfation, with a small part (approximately 5%15%) being metabolized by the cytochrome P450 pathway (CYP450) (Kalsi et al., 2011